Ravuconazole

Ravuconazole is an orally available triazole fungicide that potently inhibits the growth of a wide range of fungi (MICs range from 25 to 780 ng/ml). Like other azoles, ravuconazole inhibits cytochrome P450 (CYP) isoforms that are involved in ergosterol biosynthesis, interfering with the generation of the fungal and protozoan cell membranes. Ravuconazole specifically inhibits sterol 14alpha-demethylase (CYP51). As this enzyme is also important in the development of trypanosomes, ravuconazole is effective against T. cruzi infections in animal models of Chagas disease.Formal Name: 4-[2-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]-benzonitrile. CAS Number: 182760-06-1. Synonyms: BMS 207147, ER-30346. Molecular Formula: C22H17F2N5OS. Formula Weight: 437.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS (pH 7.2) (1:4): 0.25 mg/ml, DMSO: 20 mg/ml, Ethanol: 5 mg/ml. lambdamax: 285 nm. SMILES: FC(C=C(F)C=C1)=C1[C@](CN2N=CN=C2)(O)[C@@H](C)C3=NC(C4=CC=C(C#N)C=C4)=CS3. InChi Code: InChI=1S/C22H17F2N5OS/c1-14(21-28-20(10-31-21)16-4-2-15(9-25)3-5-16)22(30,11-29-13-26-12-27-29)18-7-6-17(23)8-19(18)24/h2-8,10,12-14,30H,11H2,1H3/t14-,22+/m0/s1. InChi Key: OPAHEYNNJWPQPX-RCDICMHDSA-N.