rac-Eletriptan-d3 (hydrobromide)

rac-Eletriptan-d3 is intended for use as an internal standard for the quantification of eletriptan (Cay-20048) by GC- or LC-MS. Eletriptan is an agonist of the serotonin (5-HT) receptor types 5-HT1B and 5-HT1D. It inhibits forskolin-induced cAMP accumulation in and induces vasoconstriction of isolated rabbit common carotid artery rings (pD2s = 7.6 and 4.9, respectively), an effect that can be blocked by the 5-HT1B antagonist SB216641 but not the 5-HT1D antagonist BRL15572. Eletriptan preferentially induces constriction of isolated human cerebral over coronary arteries (EC50s = 15.8 and 1,995 nM, respectively). Formulations containing eletriptan have been used in the treatment of migraine headache.Formal Name: 3-((1-(methyl-d3)pyrrolidin-2-yl)methyl)-5-(2-(phenylsulfonyl)ethyl)-1H-indole, monohydrobromide. Molecular Formula: C22H23D3N2O2S . HBr. Formula Weight: 466.5. Purity: >99% deuterated forms (d1-d3). Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. SMILES: O=S(CCC1=CC=C(NC=C2CC3N(C([2H])([2H])[2H])CCC3)C2=C1)(C4=CC=CC=C4)=O.Br. InChi Code: InChI=1S/C22H26N2O2S.BrH/c1-24-12-5-6-19(24)15-18-16-23-22-10-9-17(14-21(18)22)11-13-27(25,26)20-7-3-2-4-8-20,/h2-4,7-10,14,16,19,23H,5-6,11-13,15H2,1H3,1H/i1D3,. InChi Key: UTINOWOSWSPFLJ-NIIDSAIPSA-N.