rac-Benpyrine

rac-Benpyrine is an inhibitor of the protein-protein interaction between TNF-alpha and TNF receptor 1 (TNFR1, IC50 = 0.109 µM). It reduces TNF-alpha-induced cytotoxicity in L-929 fibroblasts when used at a concentration of 10 µM, as well as prevents nuclear translocation of NF-kappaB in RAW 264.7 macrophages. rac-Benpyrine (25 mg/kg) improves survival in a mouse model of LPS-induced endotoxemia and decreases disease severity in mouse models of collagen-induced arthritis and imiquimod-induced psoriasis.Formal Name: 1-(phenylmethyl)-4-(9H-purin-6-ylamino)-2-pyrrolidinone. CAS Number: 1333714-43-4. Molecular Formula: C16H16N6O. Formula Weight: 308.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 1 mg/ml. lambdamax: 267 nm. SMILES: O=C1N(CC2=CC=CC=C2)CC(NC3=NC=NC4=C3NC=N4)C1. InChi Code: InChI=1S/C16H16N6O/c23-13-6-12(8-22(13)7-11-4-2-1-3-5-11)21-16-14-15(18-9-17-14)19-10-20-16/h1-5,9-10,12H,6-8H2,(H2,17,18,19,20,21). InChi Key: HUWOMAVUXTXEKT-UHFFFAOYSA-N.