(R)-IMPP

(R)-IMPP is a cell-permeable inhibitor of the secretion of proprotein convertase subtilisin/kexin type 9 (PCSK9, IC50 = 4.8 µM). It promotes the uptake of LDL cholesterol in hepatoma cells by increasing LDL receptor levels. (R)-IMPP apparently impairs PCSK9 secretion by causing transcript-dependent inhibition of PCSK9 translation.Formal Name: N-1-isoquinolinyl-4-methoxy-N-(3R)-3-piperidinyl-benzenepropanamide. CAS Number: 2133832-83-2. Molecular Formula: C24H27N3O2. Formula Weight: 389.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 10 mg/ml. lambdamax: 220, 275, 323 nm. SMILES: COC1=CC=C(CCC(N(C2=C(C=CC=C3)C3=CC=N2)[C@H]4CNCCC4)=O)C=C1. InChi Code: InChI=1S/C24H27N3O2/c1-29-21-11-8-18(9-12-21)10-13-23(28)27(20-6-4-15-25-17-20)24-22-7-3-2-5-19(22)14-16-26-24/h2-3,5,7-9,11-12,14,16,20,25H,4,6,10,13,15,17H2,1H3/t20-/m1/s1. InChi Key: OKTGXQMSOIQCTJ-HXUWFJFHSA-N.