(R)-CPP

(R)-CPP is an NMDA receptor antagonist (Ki = 0.14 µM). It binds to NMDA receptors containing GluN2A, GluN2B, GluN2C, and GluN2D subunits with Ki values of 0.04, 0.3, 0.6, and 2 µM, respectively. It inhibits depolarization induced by NMDA in isolated hemisected frog spinal cord (pA2 = 6.56) and NMDA-induced sodium efflux from rat brain slices (pA2 = 6.2). (R)-CPP inhibits the clonic phase of sound-induced seizures in DBA/2 mice (ED50 = 65.8 µmol/kg) and the myoclonic phase of stroboscopic-induced seizures in P. papio photosensitive baboons (ED50 = 127 µmol/kg).Formal Name: (2R)-4-(3-phosphonopropyl)-2-piperazinecarboxylic acid. CAS Number: 126453-07-4. Molecular Formula: C8H17N2O5P. Formula Weight: 252.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: Water: 100mM. SMILES: OP(CCCN1CCN[C@@H](C(O)=O)C1)(O)=O. InChi Code: InChI=1S/C8H17N2O5P/c11-8(12)7-6-10(4-2-9-7)3-1-5-16(13,14)15/h7,9H,1-6H2,(H,11,12)(H2,13,14,15)/t7-/m1/s1. InChi Key: CUVGUPIVTLGRGI-SSDOTTSWSA-N.