PTACH [NCH 51]

Synthetic. Chemical. CAS: 848354-66-5. Formula: C20H26N2O2S2. MW: 390.56. Synthetic. Potent non-hydroxamate HDAC inhibitor (HDACi) (IC50: 32, 48 and 41nM for HDAC4, HDAC1 and HDAC6, respectively). Cell-permeable prodrug that is intracellularly converted to the potent HDAC inhibitor NCH 31. Predicted to exhibit a similar HDAC binding mode as that of SAHA, interacting with the active-site zinc targeting group. Shown to exhibit comparable antiproliferative and apoptotic activity as SAHA against various cancer cell lines. Inhibits growth of various cancer cells in vitro (EC50 = 1.1 - 9.1mM). Reactivates latent HIV-1 gene expression. Active against selected neurodevelopmental disorders.