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A PDHK inhibitor (IC50s = 2.07, 0.8, 21.3, and 0.77 µM for PDHK1, -2, -3, and -4, respectively), selectively binds to PDHK2 over Hsp90 (Kds = 0.239 and 47 µM, respectively), increases heart, liver, and kidney pyruvate dehydrogenase complex activity, decreases blood glucose levels in a glucose tolerance test, and reduces plasma lactate, cholesterol, and triglyceride levels, fat mass, and hepatic lipid accumulation in a mouse model of high-fat diet-induced obesity at 70 mg/kg. Formulation: A solid. InChI: InChI=1S/C14H13NO6S/c16-9-1-2-14(13(19)4-9)22(20,21)15-6-8-3-10(17)5-12(18)11(8)7-15/h1-5,16-19H,6-7H2. InChIKey: SVUZJWAAXPEMKJ-UHFFFAOYSA-N. SMILES: O=S(N1CC2=C(C1)C(O)=CC(O)=C2)(C3=CC=C(O)C=C3O)=O
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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