Protriptyline (hydrochloride)

Protriptyline is a tricyclic antidepressant. It binds to the norepinephrine and serotonin (5-HT) transporters with Kd values of 1.41 and 19.6 nM, respectively. Protriptyline also binds to histamine H1, muscarinic acetylcholine, and alpha1-adrenergic receptors (Kds = 25, 25, and 130 nM, respectively). It inhibits norepinephrine uptake into rat whole brain and hypothalamic synaptosomes (IC50s = 12 and 0.55 µM, respectively) and 5-HT uptake into rat whole brain synaptosomes (IC50 = 5.5 µM). Protriptyline (1 mg/kg, i.v.) inhibits food-induced cataplexy in narcoleptic dogs. Formulations containing protriptyline have been used in the treatment of depression.Formal Name: N-methyl-5H-dibenzo[a,d]cycloheptene-5-propanamine, monohydrochloride. CAS Number: 1225-55-4. Synonyms: Protryptyline. Molecular Formula: C19H21N . HCl. Formula Weight: 299.8. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 5 mg/ml, DMSO: 3 mg/ml, Ethanol: 5 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 294 nm. SMILES: CNCCCC1C2=C(C=CC=C2)C=CC3=C1C=CC=C3.Cl. InChi Code: InChI=1S/C19H21N.ClH/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19,/h2-5,7-10,12-13,19-20H,6,11,14H2,1H3,1H. InChi Key: OGQDIIKRQRZXJH-UHFFFAOYSA-N.