PROTAC(H-PGDS)-7

PROTAC(H-PGDS)-7 is a proteolysis-targeting chimera (PROTAC) comprised of the hematopoietic prostaglandin D synthase (H-PGDS) inhibitor TFC-007 (Cay-17971) and the cereblon inhibitor pomalidomide (Cay-19877). It induces degradation of H-PGDS in KU812 cells with a 50% degradation concentration (DC50) value of 17.3 pM, as well as decreases the production of prostaglandin D2 (PGD2) in the same cells.Formal Name: N-[4-[4-[[4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-1-piperazinyl]carbonyl]-1-piperidinyl]phenyl]-2-phenoxy-5-pyrimidinecarboxamide. CAS Number: 2761281-50-7. Synonyms: Proteolysis-targeting Chimera (Prostaglandin D Synthase (hematopoietic-type))-7. Molecular Formula: C40H38N8O7. Formula Weight: 742.8. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 10 mg/ml. SMILES: O=C(N1CCN(C2=C(C(N(C3C(NC(CC3)=O)=O)C4=O)=O)C4=CC=C2)CC1)C(CC5)CCN5C6=CC=C(NC(C7=CN=C(OC8=CC=CC=C8)N=C7)=O)C=C6. InChi Code: InChI=1S/C40H38N8O7/c49-33-14-13-32(36(51)44-33)48-38(53)30-7-4-8-31(34(30)39(48)54)46-19-21-47(22-20-46)37(52)25-15-17-45(18-16-25)28-11-9-27(10-12-28)43-35(50)26-23-41-40(42-24-26)55-29-5-2-1-3-6-29/h1-12,23-25,32H,13-22H2,(H,43,50)(H,44,49,51). InChi Key: KQNXUQJGOJWQGL-UHFFFAOYSA-N.