PROTAC Bcl2 degrader-1

Description: PROTAC Bcl2 degrader-1 is a PROTAC, which potently and selectively induces the degradation of Mcl-1 (IC50: 11.81 µM) and Bcl-2 (IC50: 4.94 µM, DC50: 3.0 µM). Target: BCL, PROTACs. Smiles: O=C1NC(=O)C(N2C(=O)C=3C=CC=C(NCCOCCOCCNC(=O)CCCCC(=O)NCCN4C(=O)C5=CC=CC=6C(SC7=CC=C(Br)C=C7)=CC=C(C4=O)C56)C3C2=O)CC1. References: Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Aug 21.