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Item number: Cay45385-1

PROTAC Bcl-2 degrader-1 is a proteolysis-targeting chimera (PROTAC) composed of a Bcl-2 inhibitor conjugated to the cereblon (CRBN) inhibitor pomalidomide (Cay19877) via a PEG linker. It induces the degradation of Bcl-2 in HeLa cells with a half-maximal degradation concentration (DC50) value of 3 µM. PROTAC Bcl-2...

Keywords:	PROTAC BCL2 Degrader-1, Proteolysis-targeting Chimera Bcl-2 Degrader-1, Proteolysis-targeting Chimera BCL2 Degrader-1,...
Application:	Bcl-2 degradation driving PROTAC
CAS	2378801-85-3
MW:	941.85 D

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PROTAC Bcl2 degrader-1

Item number: TGM-T10485-100mg

Description: PROTAC Bcl2 degrader-1 is a PROTAC, which potently and selectively induces the degradation of Mcl-1 (IC50: 11.81 µM) and Bcl-2 (IC50: 4.94 µM, DC50: 3.0 µM). Target: BCL, PROTACs. Smiles:...

CAS	2378801-85-3
MW:	941.84 D

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