(±)-Propranolol (hydrochloride)

(±)-Propranolol is a beta-adrenergic receptor (beta-AR) antagonist (Kds = 6.91, 0.832, and 117.49 nM for human beta1-, beta2-, and beta3-ARs, respectively). It reduces mean blood pressure, resting heart rate, and contractility and increases AV conduction time in dogs. (±)-Propranolol restores normal sinus rhythm in dogs with ouabain-induced arrhythmias (ED50 = 3.8 mg/kg). It also acts as a non-specific serotonin receptor antagonist, reducing tranylcypromine/L-tryptophan-induced hyperactivity in rats. Formulations containing (±)-propranolol have been used for the treatment of hypertension, angina pectoris, and cardiac ischemia.Formal Name: 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanol, monohydrochloride. CAS Number: 318-98-9. Synonyms: ICI 45520, NSC 91523. Molecular Formula: C16H21NO2 . HCl. Formula Weight: 295.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 15 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 215 nm. SMILES: OC(CNC(C)C)COC1=C2C(C=CC=C2)=CC=C1.Cl. InChi Code: InChI=1S/C16H21NO2.ClH/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16,/h3-9,12,14,17-18H,10-11H2,1-2H3,1H. InChi Key: ZMRUPTIKESYGQW-UHFFFAOYSA-N.