155 products were found matching "K04141"!

Recombinant CHO-K1 cells stably overexpress human adrenoceptor beta 1 (ADRB1) on the surface and contain high levels of G protein Galphas to couple with the receptor in downstream signaling pathways.

DL 071-IT is an antagonist of beta-adrenergic receptors (beta-ARs). InChI: InChI=1S/C15H21NO4.ClH/c1-15(2,3)16-7-11(17)9-19-12-6-4-5-10-8-20-14(18)13(10)12,/h4-6,11,16-17H,7-9H2,1-3H3,1H InChIKey: KTIQCDLYPPAYBF-UHFFFAOYSA-N SMILES: O=C1OCC2=C1C(OCC(CNC(C)(C)C)O)=CC=C2.Cl

Landiolol is an antagonist of the beta1-adrenergic receptor (beta1-AR). It selectively induces relaxation of isolated and perfused guinea pig atrial strips that endogenously express beta1-ARs over isolated and perfused guinea pig tracheal strips that endogenously express beta2-ARs (pA2s = 6. and 4. respectively)....

A ß1-adrenergic receptor antagonist (IC50 = 4.2 nM), selective for ß1-adrenergic receptors over ß2-adrenergic receptors (IC50 = 678 nM), acts as a partial agonist at ß1- and ß2-adrenergic receptors, inducing cAMP accumulation in CHO-K1 cells expressing the human receptors (EC50s = 0.81 and 60.26 nM, respectively)....

Isoproterenol is an agonist of beta1- and beta2-adrenergic receptors (beta1- and beta2-ARs, Kis = 224 and 458 nM, respectively. It is selective for beta1- and beta2-ARs over beta3-ARs (Ki = 1,570 nM). Isoproterenol inhibits contractions in isolated field-stimulated rat vas deferens (EC50 = 45.6 nM). In vivo,...

A b-Adrenergic receptor selective antagonist used as a antiglaucoma agent.

(±)-Talinolol is a beta1-selective adrenoceptor antagonist well known for its cardioprotective and antihypertensive activity. By blocking beta1-adrenergic receptors, talinolol delays the conduction of stimuli in the AV node, reduces the sino-atrial conduction time, and impedes the sinus node automaticity. Because...

Metoprolol tartrate is a beta1-adrenergic blocker.

Propranolol HCl is a sympatholytic non-selective beta blocker. Sympatholytics are used to treat hypertension, anxiety and panic.

Esmolol is a beta1-adrenergic receptor (beta1-AR) antagonist. It binds to beta1-ARs (Kd = 100 nM in isolated cardiac myocytes) and is 34-fold selective for beta1- over beta2-ARs. Esmolol also inhibits L-type Ca2+ currents (ICa.L) and the fast Na+ current (INa) in rat cardiac myocytes (IC50s = 50 and 169 µM,...

Bufuralol is a non-selective antagonist of beta-adrenergic receptors (beta-ARs) that also has partial agonist activity. It decreases mean arterial blood pressure and increases abdominal aortic blood flow in anesthetized cats when administered intravenously at doses of 0.3 and 1 mg/kg. Bufuralol is hydroxylated at...

Sotalol is a non-selective antagonist of beta-adrenergic receptors (beta-ARs, IC50s = 8.9 and 5.2 µM for beta1- and beta2-ARs, respectively) and a class III antiarrhythmic agent. It decreases delayed outward potassium currents (IK) in guinea pig ventricular cells and prolongs action potential duration in...