Propenyl-L-NIO (hydrochloride)

Propenyl-L-NIO (hydrochloride)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10011724-5 5 mg -

6 - 10 business days*

64.00€
Cay10011724-10 10 mg -

6 - 10 business days*

122.00€
Cay10011724-25 25 mg -

6 - 10 business days*

288.00€
Cay10011724-50 50 mg -

6 - 10 business days*

510.00€
 
Propenyl-L-NIO (hydrochloride) (ENIPO) is a potent, selective inhibitor of iNOS. The Ki values... more
Product information "Propenyl-L-NIO (hydrochloride)"
Propenyl-L-NIO (hydrochloride) (ENIPO) is a potent, selective inhibitor of iNOS. The Ki values for inhibition of iNOS, nNOS, and eNOS by ENIPO are 17, 10.3 and 58.2 µM, respectively, as determined using initial rate binding kinetics. However, ENIPO is a time-dependent inhibitor that, with longer incubations, demonstrates reversible tight binding inhibition that is selective for iNOS over nNOS or eNOS. This selectivity results from iNOS exhibiting a 4-fold faster binding and 10-fold slower dissociation with ENIPO compared to nNOS. Ki values for ENIPO binding to iNOS and nNOS are 0.56 and 6 µM, respectively. Accurate determination of the Ki value of ENIPO for eNOS has not been determined but is expected to be 50-fold less than iNOS. Formal Name: N5-[(3E)-1-imino-3-pentenyl]-L-ornithine, monohydrochloride. Synonyms: ENIPO. Molecular Formula: C10H19N3O2 . HCl. Formula Weight: 249.7. Purity: >90%. Formulation: A crystalline solid. Solubility: DMF: 2.5 mg/ml, DMSO: 2 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: C/C=C/CC(=N)NCCC[C@H](N)C(=O)O. InChi Code: InChI=1S/C10H19N3O2.ClH/c1-2-3-6-9(12)13-7-4-5-8(11)10(14)15,/h2-3,8H,4-7,11H2,1H3,(H2,12,13)(H,14,15),1H/b3-2+,. InChi Key: CMMBMUQLXSZAKX-SQQVDAMQSA-N.
Keywords: ENIPO, N5-[(3E)-1-imino-3-pentenyl]-L-ornithine, monohydrochloride
Supplier: Cayman Chemical
Supplier-Nr: 10011724

Properties

Application: INOS inhibitor
MW: 249.7 D
Formula: C10H19N3O2 . HCl
Purity: >90%
Format: Crystalline Solid

Database Information

CAS : 150403-97-7| Find alternatives
KEGG ID : K13241 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H315, H319, H335
P Phrases: P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362+364, P403+233, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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