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Statistics & Tracking
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Ethyl-L-NIO, the saturated analog of vinyl-L-NIO, is a modestly selective NOS inhibitor. The Ki values for inhibition of nNOS, eNOS, and iNOS by ethyl-L-NIO are 5.3, 18, and 12 µM, respectively, as determined using initial rate measurements. However when evaluating the Ki/Km ratio, ethyl-L-NIO does not show biologically significant selectivity for nNOS over eNOS, and instead favors iNOS (Ki/Km = 3.79, 5, and 0.96 µM, respectively). Although ethyl-L-NIO inhibits nNOS, it does not inactivate nNOS in the presence of NADPH and O2. Formal Name: N5-(1-iminobutyl)-L-ornithine, monohydrochloride. CAS Number: 150403-97-7. Synonyms: L-N5-(1-Iminobutyl)ornithine hydrochloride. Molecular Formula: C9H19N3O2 . HCl. Formula Weight: 237.7. Purity: >95%. Formulation: A crystalline solid. Solubility: DMF: 0.3 mg/ml, DMSO: 2 mg/ml, Ethanol: 2.5 mg/ml, PBS (pH 7.2): 5 mg/ml. SMILES: CCCC(=N)NCCC[C@H](N)C(=O)OCl. InChi Code: InChI=1S/C9H19N3O2.ClH/c1-2-4-8(11)12-6-3-5-7(10)9(13)14,/h7H,2-6,10H2,1H3,(H2,11,12)(H,13,14),1H. InChi Key: DWNWLIPSWIUXRG-UHFFFAOYSA-N.