Propafenone (hydrochloride)

Propafenone is a class I antiarrhythmic agent. It inhibits calcium currents (ICa) in isolated guinea pig ventricular myocytes (IC50 = 5 µM), as well as ATP-sensitive potassium currents (IKATP) in isolated rabbit atrial and ventricular monocytes (IC50s = 1.26 and 4.94 µM, respectively). Propafenone also blocks sodium (INa), potassium (IK), and transient outward potassium currents in various cardiac cells. In vivo, propafenone (2 and 3 mg/kg, i.v.) reverses sinus rhythm in a dog model of barium chloride-induced ventricular arrhythmia. Formulations containing propafenone have been used in the treatment of cardiac arrhythmias.Formal Name: 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-1-propanone, monohydrochloride. CAS Number: 34183-22-7. Molecular Formula: C21H27NO3 . HCl. Formula Weight: 377.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml, Ethanol: 0.3 mg/ml. lambdamax: 209, 247, 303 nm. SMILES: O=C(C1=CC=CC=C1OCC(CNCCC)O)CCC2=CC=CC=C2.Cl. InChi Code: InChI=1S/C21H27NO3.ClH/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17,/h3-11,18,22-23H,2,12-16H2,1H3,1H. InChi Key: XWIHRGFIPXWGEF-UHFFFAOYSA-N.