44 products were found matching "K04834"!

Levobupivacaine-d9 is intended for use as an internal standard for the quantification of levobupivacaine (Cay-31596) by GC- or LC-MS. Levobupivacaine is a sodium channel blocker and local anesthetic, as well as the levorotary stereoisomer of bupivacaine (Cay-16618). It inhibits cardiac sodium channel currents (INa)...

Eslicarbazepine is a voltage-gated sodium channel (Nav) inhibitor and an active metabolite of the prodrug eslicarbazepine acetate (Cay-23656). It enhances slow activation of voltage-gated sodium channels, reducing channel availability. Eslicarbazepine is protective against seizures induced by maximal electroshock...

Fenvalerate is a pyrethroid ester insecticide and acaricide. It is a slow activator of voltage-gated sodium channel 1.8 (Nav1.8). It induces mortality in pyrethroid-susceptible and -resistant strains of M. domestica (LD50s = 0.014-5 µg/fly). Fenvalerate also induces mortality in tobacco budworm larvae but is...

Mepivacaine (Cay-23402) is an analytical reference standard that is categorized as an anesthetic. This product is intended for research and forensic applications.Formal Name: N-(2,6-dimethylphenyl)-1-methyl-2-piperidinecarboxamide. CAS Number: 96-88-8. Molecular Formula: C15H22N2O. Formula Weight: 246.4. Purity:...

Tetracaine (Cay-30059) is an analytical reference standard categorized as an anesthetic. Tetracaine has been found as an adulterant in products marketed as male sexual function enhancers. This product is intended for research and forensic applications.Formal Name: 4-(butylamino)-benzoic acid, 2-(dimethylamino)ethyl...

Propafenone is a class I antiarrhythmic agent. It inhibits calcium currents (ICa) in isolated guinea pig ventricular myocytes (IC50 = 5 µM), as well as ATP-sensitive potassium currents (IKATP) in isolated rabbit atrial and ventricular monocytes (IC50s = 1.26 and 4.94 µM, respectively). Propafenone also blocks sodium...

Lamotrigine is an anticonvulsant. It inhibits voltage-gated sodium channels (Nav) in HEK293 cells expressing recombinant human Nav1.2, Nav1.5, or Nav1.8 (IC50s = 10, 62, and 96 µM, respectively), as well as high voltage-activated calcium currents in isolated rat cortical neurons (IC50 = 12.3 µM), an effect that can...

Brevetoxin B is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. It binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50 = 15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal,...

Mexiletine is a voltage-gated sodium channel blocker and class Ib antiarrhythmic agent that preferentially binds to open/inactive channels. It inhibits aconitine-induced dysrhythmias in mice with ED50 values of 57 and 107 mg/kg for intraperitoneal and oral administration, respectively. Mexiletine decreases or...

Anti-Nav1.2 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with Nav1.2 from Mouse, Human, and Rat based on 100% homology with the immunizing sequence. Cross-reactivity with Nav1.2 from other sources has not been determined. Ion Channels research. Protein...

(-)-Ropivacaine-d7 is intended for use as an internal standard for the quantification of (-)-ropivacaine (Cay-21422) by GC- or LC-MS. (-)-Ropivacaine is a potent and reversible blocker of sodium channels in nerve fibers. In vivo, (-)-ropivacaine induces complete impairment of proprioception, motor function, and...

Lamotrigine-d3 is intended for use as an internal standard for the quantification of lamotrigine (Cay-15428) by GC- or LC-MS. Lamotrigine is an anticonvulsant. It inhibits voltage-gated sodium channels (Nav) in HEK293 cells expressing recombinant human Nav1.2, Nav1.5, or Nav1.8 (IC50s = 10, 62, and 96 µM,...