Procaterol (hydrochloride)

Procaterol is an agonist of beta2-adrenergic receptors (beta2-ARs). It binds to (Kd = 46 pM), and is selective for, beta2-ARs over beta1-ARs (Kd = 4,000 pM). Procaterol binds more potently to beta2-ARs in isolated guinea pig lung than to beta1-ARs in isolated guinea pig cardiac ventricle in the presence (IC50s = 175 and 1,660 nM, respectively) and absence of GTP (Cay-16060, IC50s = 55.1 and 1,660 nM, respectively). It inhibits contractions induced by acetylcholine (Cay-23829) in isolated guinea pig trachea (EC50 = 10.5 nM). In vivo, procaterol inhibits histamine-induced airflow obstruction in a guinea pig model of ovalbumin-sensitized asthma when administered via inhalation at a dose of 10 µg/ml.Formal Name: rel-8-hydroxy-5-[(1R,2S)-1-hydroxy-2-[(1-methylethyl)amino]butyl]-2(1H)-quinolinone, monohydrochloride. CAS Number: 62929-91-3. Molecular Formula: C16H22N2O3 . HCl. Formula Weight: 326.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:4): 0.20 mg/ml. lambdamax: 237, 262, 297 nm. SMILES: O=C1C=CC2=C([C@@H]([C@H](NC(C)C)CC)O)C=CC(O)=C2N1.Cl. InChi Code: InChI=1S/C16H22N2O3.ClH/c1-4-12(17-9(2)3)16(21)11-5-7-13(19)15-10(11)6-8-14(20)18-15,/h5-9,12,16-17,19,21H,4H2,1-3H3,(H,18,20),1H/t12-,16+,/m1./s1. InChi Key: AEQDBKHAAWUCMT-KKJWGQAZSA-N.