Pralatrexate
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: Pralatrexate (10-Propargyl-10-deazaaminopterin) is a folate analogue inhibitor of... more
Product information "Pralatrexate"
Description: Pralatrexate (10-Propargyl-10-deazaaminopterin) is a folate analogue inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities. Target: DHFR, Apoptosis, TAM Receptor, Antifolate. Smiles: Nc1nc(N)c2nc(CC(CC#C)c3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cnc2n1. References: Marchi E, et al. Clin Cancer Res, 2010, 16(14), 3648-3658.
| Keywords: | 10-Propargyl-10-deazaaminopterin, Folotyn |
| Supplier: | TargetMol |
| Supplier-Nr: | T6120 |
Properties
| Application: | Targets dihydrofolate reductase [EC:1.5.1.3] (DHFR, folA) |
| MW: | 477.47 D |
| Formula: | C23H23N7O5 |
Database Information
| CAS : | 146464-95-1| Matching products |
| KEGG ID : | K00287 | Matching products |
| Protein Atlas Nr. : | Gene Regulation |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Danger |
| GHS Hazard Pictograms: |
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| H Phrases: | H301, H360 |
| P Phrases: | P201, P202, P264, P270, P280, P321, P330, P301+P310, P308+P313, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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