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Item number: Cay23689-10

Pralatrexate is a dihydrofolate reductase (DHFR) inhibitor (Ki = 13.4 pM) and antifolate. It inhibits growth of CCRF-CEM acute lymphocytic leukemia cells (IC50 = 0.04 µM), MDA-468, SK-BR-3, and ZR-75-1 breast cancer cells (IC50s = 0.11, 0.28, and 0.26 µM, respectively), and SK-LC8 and SK-LC16 non-small cell lung...

Keywords:	10-Propargyl-10-deazaaminopterin, NSC 754230, PDX,...
Application:	Dihydrofolate reductase (DHFR) inhibitor
CAS	146464-95-1
MW:	477.5 D

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Pralatrexate

Item number: TGM-T6120-100mg

Description: Pralatrexate (10-Propargyl-10-deazaaminopterin) is a folate analogue inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities. Target: DHFR, Apoptosis, TAM Receptor, Antifolate. Smiles:...

Keywords:	10-Propargyl-10-deazaaminopterin, Folotyn
Application:	Targets dihydrofolate reductase [EC:1.5.1.3] (DHFR, folA)
CAS	146464-95-1
MW:	477.47 D

From 30.00€ *

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