Pindolol

Pindolol is an antagonist of beta1- and beta2-adrenergic receptors (beta1- and beta2-ARs, Kis = 2.6 and 4.8 nM, respectively) and a partial agonist of the beta3-AR, stimulating adenylyl cyclase in membranes of cells expressing the human receptor. It is also an antagonist of the serotonin 5-HT1A receptor (Ki = 81.1 nM for inhibition of 5-HT-stimulated GTPgammaS binding). Pindolol inhibits isoproterenol-induced tachycardia in anesthetized cats (ED50 = 1.8 µg/kg). It also decreases mean blood pressure in conscious spontaneously hypertensive rats when administered at a dose of 30 mg/kg per day, but concomitantly increases heart rate. Formulations containing pindolol have been used in the treatment of hypertension.Formal Name: 1-(1H-indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol. CAS Number: 13523-86-9. Synonyms: DL-Pindolol. Molecular Formula: C14H20N2O2. Formula Weight: 248.3. Purity: >99%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/ml, DMSO: 15 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 5 mg/ml. lambdamax: 218, 288 nm. SMILES: OC(CNC(C)C)COC1=C2C(NC=C2)=CC=C1. InChi Code: InChI=1S/C14H20N2O2/c1-10(2)16-8-11(17)9-18-14-5-3-4-13-12(14)6-7-15-13/h3-7,10-11,15-17H,8-9H2,1-2H3. InChi Key: JZQKKSLKJUAGIC-UHFFFAOYSA-N.