PI3K/Akt/mTOR-IN-2

PI3K/Akt/mTOR-IN-2 is an inhibitor of the PI3K/Akt/mTOR pathway. It reduces the phosphorylation of Akt and mTOR when used at a concentration of 2 µM and decreases PI3K, Akt, and mTOR levels at 4 µM. PI3K/Akt/mTOR-IN-2 is cytotoxic to A549, BGC-823, PC3, MCF-7, and MDA-MB-231 cancer cells (IC50s = 14. 9. 9. 7. and 2. µM, respectively). It induces apoptosis and cell cycle arrest at the G0/G1 phase in MDA-MB-231 breast cancer cells. PI3K/Akt/mTOR-IN-2 decreases the mitochondrial membrane potential and glutathione (GSH) levels and increases reactive oxygen species (ROS) and intracellular calcium levels in MDA-MB-231 cells in a concentration-dependent manner. Formal Name: 1-(3,5-difluorophenyl)-1,3,4,9-tetrahydro-pyrano[3,4-b]indole. CAS Number: 2757804-89-8. Synonyms: Phosphatidylinositol 3-Kinase/Protein Kinase B/Mammalian Target of Rapamycin-IN-2 Phosphatidylinositol 3-Kinase/Protein Kinase B/Mammalian Target of Rapamycin Inhibitor 2. Molecular Formula: C17H13F2NO. Formula Weight: 285.3. Purity: >98%. Formulation (Request formulation change): A solid. Solubility: DMSO: Sparingly soluble: 1-10 mg/ml Ethanol: Sparingly soluble: 1-10 mg/ml. SMILES: FC1=CC(C2OCCC3=C2NC4=C3C=CC=C4)=CC(F)=C1. InChi Code: InChI=1S/C17H13F2NO/c18-11-7-10(8-12(19)9-11)17-16-14(5-6-21-17)13-3-1-2-4-15(13)20-16/h1-4,7-9,17,20H,5-6H2. InChi Key: XBYJYKHTEFYLFX-UHFFFAOYSA-N. Storage: -20°C. Stability: > 4 years.