PI3-Kinase Inhibitor

PI3-Kinase inhibitor is an inhibitor of PI3Kgamma (IC50 = 1.5 nM). It is selective for PI3Kgamma over PI3Kalpha, PI3Kbeta, and PI3Kdelta (IC50s = 3,333, >10,000, and >1,000 nM, respectively). PI3-Kinase inhibitor (100 mg/kg) inhibits tumor growth in a 4T1 murine mammary cancer model. It decreases disease severity in a mouse model of experimental autoimmune encephalomyelitis (EAE) when administered at doses of 20 or 80 mg/kg. SMILES C[C@H](N(CC1=CC(C2=C(C)N=C(NC(C)=O)S2)=NC(N3CCOCC3)=C14)C4=O)C5CC5 InChi Code InChI=1S/C22H27N5O3S/c1-12-19(31-22(23-12)24-14(3)28)17-10-16-11-27(13(2)15-4-5-15)21(29)18(16)20(25-17)26-6-8-30-9-7-26/h10,13,15H,4-9,11H2,1-3H3,(H,23,24,28)/t13-/m0/s1 InChi Key FEOYQQKILUILEH-ZDUSSCGKSA-N