45 products were found matching "K21289"!

PI3-Kinase inhibitor is an inhibitor of PI3Kgamma (IC50 = 1.5 nM). It is selective for PI3Kgamma over PI3Kalpha, PI3Kbeta, and PI3Kdelta (IC50s = 3,333, >10,000, and >1,000 nM, respectively). PI3-Kinase inhibitor (100 mg/kg) inhibits tumor growth in a 4T1 murine mammary cancer model. It decreases disease severity in...

TG 100-115 is an inhibitor of PI3Kgamma and PI3Kdelta (IC50s = 0. and 0. µM, respectively). It is selective for PI3Kgamma and PI3Kdelta over PI3Kalpha and PI3Kbeta (IC50s = 1. and 1. µM) and a panel of 140 additional kinases but does inhibit eight kinases in the panel. TG 100-115 also inhibits the kinase activity of...

IPI-549 is an inhibitor of PI3Kgamma (IC50s = 16, 3,200, 3,500, and >8,400 nM for PI3Kgamma, PI3Kalpha, PI3Kbeta, and PI3Kdelta, respectively). It is greater than 100-fold selective for PI3Kgamma over a panel of 468 mutant and nonmutant protein and lipid kinases, including Class II PI3K isoforms, and a panel of 80 G...

Active human p120gamma ( GenBank Accession No. AF327656), full length with N-terminal His tag, MW=131 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell...

CH5132799 is an inhibitor of class I PI3K isoforms (IC50s = 14, 120, 500, and 36 nM for PI3Kalpha, PI3Kbeta, PI3Kdelta, and PI3Kgamma, respectively). It is selective for these PI3K isoforms over PI3KC2alpha and PI3KC2beta, which are class II PI3Ks, Vps34, a class III PI3K, and mTOR (IC50s = 5,300, >10,000, >10,000,...

Selective inhibitor of the gamma isoform of PI3K (PI3Kgamma).

The PI3Kgamma (p110gamma/PIK3R5) Assay Kit is designed to measure PI3Kgamma activity for screening and profiling applications, using ADP-Glo(R) Kinase Assay as a detection reagent.

PKI-402 is a dual inhibitor of PI3K and mammalian target of rapamycin (mTOR, IC50s = 1.4, 9.2, and 1.7 nM for PI3Kalpha, PI3Kgamma, and mTOR, respectively). It reduces proliferation of MDA-MB-361 and PC3 cancer cells (IC50s = 8 and 21 nM, respectively) and inhibits phosphorylation of Akt in MDA-MB-361 cells (IC50 =...

Voxtalisib is a dual inhibitor of PI3K and mammalian target of rapamycin complex (mTORC, IC50s = 39, 110, 43, 9, 160, and 910 nM for PI3Kalpha, PI3Kbeta, PI3Kdelta, PI3Kgamma, mTORC1, and mTORC2, respectively). It is selective for these kinases over vacuolar protein sorting 34 (VPS34, IC50 = 9,100 nM) and a panel of...

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform is an enzyme that in humans is encoded by the PIK3CG gene. Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein...

Protein function: Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling...