PHPS1

PHPS1 is a cell-permeable, phosphotyrosine mimetic that inhibits the Src homology region 2 domain-containing phosphatase (SHP)-2 (IC50 = 2.1 µM, Ki = 0.73 µM). It is selective for SHP-2, inhibiting ECPTP, PTP1B, SHP-1, and mycobacterium MptpA at relatively higher concentrations (IC50s = 5.4, 19, 30, and 39 µM, respectively). PHPS1 has been shown to inhibit SHP-2-dependent cellular signaling and tumor cell colony formation.Formal Name: 4-[2-[1,5-dihydro-3-(4-nitrophenyl)-5-oxo-1-phenyl-4H-pyrazol-4-ylidene]hydrazinyl]-benzenesulfonic acid. CAS Number: 314291-83-3. Synonyms: Phenylhydrazonopyrazolone sulfonate 1, Protein Tyrosine Phosphatase Inhibitor V, PTP Inhibitor V. Molecular Formula: C21H15N5O6S. Formula Weight: 465.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: :, DMF: 5 mg/mL, DMSO: 5 mg/mL, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL. lambdamax: 244, 299, 411 nm. SMILES: O=C1N(C2=CC=CC=C2)N=C(C3=CC=C([N+]([O-])=O)C=C3)/C1=N\NC4=CC=C(S(O)(=O)=O)C=C4. InChi Code: InChI=1S/C21H15N5O6S/c27-21-20(23-22-15-8-12-18(13-9-15)33(30,31)32)19(14-6-10-17(11-7-14)26(28)29)24-25(21)16-4-2-1-3-5-16/h1-13,22H,(H,30,31,32)/b23-20+. InChi Key: VIQSBJOMLQLAKC-BSYVCWPDSA-N.