PHOME

PHOME
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10009134-1 1 mg -

6 - 10 business days*

27.00€
Cay10009134-5 5 mg -

6 - 10 business days*

119.00€
Cay10009134-10 10 mg -

6 - 10 business days*

210.00€
Cay10009134-50 50 mg -

6 - 10 business days*

919.00€
 
EpETrE metabolizes arachidonic acid such as 11(12-EpETrE and 14(15)-EpETrE have been identified... more
Product information "PHOME"
EpETrE metabolizes arachidonic acid such as 11(12-EpETrE and 14(15)-EpETrE have been identified as endothelium derived hyperpolarizing factors with vasodilator activity. Soluble epoxide hydrolase (sEH) catalyzes the conversion of EpETrEs to the corresponding DiHETrEs thereby diminishing their activity. Inhibitors of sEH may therefore have clinical utility for treating hypertension and systemic inflammation. PHOME is a fluorogenic substrate for human sEH which displays good aqueous stability and solubility making it ideal for high throughput screening (HTS) programs. Hydrolysis of the substrate yields a highly fluorescent product that can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. This fluorescent assay has a sensitivity that is 100 times greater than previously used spectrophotometric assays. NOTE: This substrate should only be used with the pure EH. If this substrate is used with crude enzyme preparations it is critical that all esterase activity is removed or inhibited, such as with organophosphate or a trifluoroketone inhibitor, and that glutathione is depleted and/or glutathione S-transferase is inhibited. Formal Name: 3-phenyl-cyano(6-methoxy-2-naphthalenyl)methyl ester-2-oxiraneacetic acid. CAS Number: 1028430-42-3. Molecular Formula: C23H19NO4. Formula Weight: 373.4. Purity: >98%. Formulation: A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml. lambdamax: 234 nm. SMILES: COc1ccc2cc(ccc2c1)C(CN)OC(=O)CC1OC1c1ccccc1. InChi Code: InChI=1S/C23H19NO4/c1-26-19-10-9-16-11-18(8-7-17(16)12-19)21(14-24)27-22(25)13-20-23(28-20)15-5-3-2-4-6-15/h2-12,20-21,23H,13H2,1H3. InChi Key: NZOVBSWOWQLAJG-UHFFFAOYSA-N.
Keywords: 3-phenyl-cyano(6-methoxy-2-naphthalenyl)methyl ester-2-oxiraneacetic acid
Supplier: Cayman Chemical
Supplier-Nr: 10009134

Properties

Application: SEH inhibitor screening
MW: 373.4 D
Formula: C23H19NO4
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 1028430-42-3| Find alternatives
KEGG ID : K08726 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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