Philanthotoxin 74 (hydrochloride)

Philanthotoxin 74 (PhTx-74) is a synthetic analog of the naturally-occurring wasp venom toxin philanthotoxin-4,3,3. It is a subtype-selective AMPA receptor antagonist that inhibits homomeric GluR1 and GluR3 as well as heteromeric GluR1/2 receptors (80-100% of glutamate-evoked currents inhibited at 100 µM). It exhibits minimal to no effect on monomeric GluR2 or heteromeric GluR2/3 receptors at concentrations up to 500 µM. PhTx-74 inhibits the GluR5(Q) receptor with a Ki value of 0.29 µM.Formal Name: N-[7-[(4-aminobutyl)amino]heptyl]-4-hydroxy-alphaS-[(1-oxobutyl)amino]-benzenepropanamide, dihydrochloride. CAS Number: 1227301-51-0. Synonyms: PhTx-74. Molecular Formula: C24H42N4O3 . 2HCl. Formula Weight: 507.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 100 mM, Water: 100 mM. SMILES: OC1=CC=C(C[C@H](NC(CCC)=O)C(NCCCCCCCNCCCCN)=O)C=C1.Cl.Cl. InChi Code: InChI=1S/C24H42N4O3.2ClH/c1-2-10-23(30)28-22(19-20-11-13-21(29)14-12-20)24(31)27-18-8-5-3-4-7-16-26-17-9-6-15-25,,/h11-14,22,26,29H,2-10,15-19,25H2,1H3,(H,27,31)(H,28,30),2*1H/t22-,,/m0../s1. InChi Key: HWTJQQMIKVJWLH-IKXQUJFKSA-N.