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Item number: Cay14607-1

Philanthotoxin 74 (PhTx-74) is a synthetic analog of the naturally-occurring wasp venom toxin philanthotoxin-4,3,3. It is a subtype-selective AMPA receptor antagonist that inhibits homomeric GluR1 and GluR3 as well as heteromeric GluR1/2 receptors (80-100% of glutamate-evoked currents inhibited at 100 µM). It...

Keywords:	PhTx-74, N-[7-[(4-aminobutyl)amino]heptyl]-4-hydroxy-alphaS-[(1-oxobutyl)amino]-benzenepropanamide, dihydrochloride
Application:	Forensic studies
CAS	1227301-51-0
MW:	507.5 D

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Philanthotoxin 74 dihydrochloride

Item number: TGM-T16524-1mg

Description: Philanthotoxin 74 dihydrochloride is an antagonist of AMPAR with IC50s of 263 and 296 nM for GluR3 and GluR1. Target: iGluR, GluR. Smiles: OC(C=C1)=CC=C1C[C@H](NC(CCC)=O)C(NCCCCCCCNC CCCN)=O.Cl.Cl. References: Poulsen MH, et al. Evaluation of PhTX-74 as subtype-selective inhibitor of GluA2-containing...

Keywords:	PhTx 74 dihydrochloride, PhTx-74 HCl
CAS	1227301-51-0
MW:	507.54 D

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