Phenyl Sulfate

Phenyl sulfate is a gut microbiota-derived metabolite of tyrosine and a uremic toxin. It reduces survival of, as well as decreases glutathione (GSH) levels and induces mitochondrial dysfunction in, differentiated human urinary podocyte-like epithelial cells (HUPECs) when used at a concentration of 30 µM. Phenyl sulfate (50 mg/kg) induces podocyte damage and albuminuria in a db/db mouse model of diabetes. Increased plasma levels of phenyl sulfate correlate with the progression of albuminuria in patients with diabetic kidney disease.Formal Name: sulfuric acid, monophenyl ester. CAS Number: 937-34-8. Molecular Formula: C6H6O4S. Formula Weight: 174.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 17.4 mg/ml, Water: 37.75 mg/ml. SMILES: O=S(O)(OC1=CC=CC=C1)=O. InChi Code: InChI=1S/C6H6O4S/c7-11(8,9)10-6-4-2-1-3-5-6/h1-5H,(H,7,8,9). InChi Key: CTYRPMDGLDAWRQ-UHFFFAOYSA-N.