Phenyl sulfate is a gut microbiota-derived metabolite of tyrosine and a uremic toxin. It reduces survival of, as well as decreases glutathione (GSH) levels and induces mitochondrial dysfunction in, differentiated human urinary podocyte-like epithelial cells (HUPECs) when used at a concentration of 30 µM. Phenyl...

Description: Phenyl sulfate, an orally active metabolite derived from gut microbiota, induces albuminuria and podocyte damage in diabetes experimental models. It serves as a potential disease marker and therapeutic target for diabetic kidney disease [1]. Target: Endogenous Metabolite. Smiles: O=S(=O)(O)OC=1C=CC=CC1