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Description: PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel, eliciting TrpA1-mediated nocifensive behavior in mouse, with EC50 values of 97 nM and 23 nM for [rTrpA1] and [hTrpA1], respectively. Target: TRP/TRPV Channel. Smiles: CC(C)CNc1nc(ncc1C(=O)NCc1ccccc1)N1CCN(CC2CCCOC2)CC1. References: Ryckmans T,etal.Design and pharmacological evaluation of PF-4840154, a non-electrophilic reference agonist of the TrpA1 channel.Bioorg Med Chem Lett. 2011 Aug 15,21(16):4857-9.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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