PF-3644022
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: PF-3644022 is an effective, selective, and ATP-competitive MAPKAPK2 (MK2) inhibitor... more
Product information "PF-3644022"
Description: PF-3644022 is an effective, selective, and ATP-competitive MAPKAPK2 (MK2) inhibitor (IC50: 5.2 nM and a Ki of 3 nM). PF-3644022 potently inhibits TNFalpha production and has an anti-inflammatory effect. PF-3644022 also inhibits MK3 and p38 regulated/activated kinase (PRAK) (IC50s: 53 nM and 5.0 nM, respectively). Target: p38 MAPK, MAPK, Serine Protease. Smiles: C[C@@H]1CNc2c(sc3ccc4nc(ccc4c23)-c2ccc(C)nc2)C(=O)N1. References: Mourey RJ, et al. A benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor alpha production and has oral anti-inflammatory efficacy in acute and chronic models of inflammation. J Pharmacol Exp Ther. 2010 Jun,333(3):797-807
| Supplier: | TargetMol |
| Supplier-Nr: | T16501 |
Properties
| Application: | MAPK-activated protein kinase 2 (MK2, MAPKAPK2) inhibitor |
| MW: | 374.46 D |
| Formula: | C21H18N4OS |
Database Information
| CAS : | 1276121-88-0| Matching products |
| KEGG ID : | K04443 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H302, H319 |
| P Phrases: | P264, P270, P280, P330, P301+P310, P305+P351+P338, P337+P313, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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