PF-3450074

PF-3450074 (PF74) is an inhibitor of HIV-1 capsid protein. It reduces viral infectivity in HeLa cells infected with wild-type HIV-1 but not P38A, E45A, Q63A/Q67A, or Q219A capsid protein mutant HIV-1, simian immunodeficiency virus, or murine leukemia virus when used at a concentration of 10 µM. PF74 (0.62-10 µM) reduces capsid protein levels in HIV-1 viral cores.Formal Name: 2-methyl-N-[(1S)-2-(methylphenylamino)-2-oxo-1-(phenylmethyl)ethyl]-1H-indole-3-acetamide. CAS Number: 1352879-65-2. Synonyms: PF74. Molecular Formula: C27H27N3O2. Formula Weight: 425.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 1 mg/ml, DMSO: 2 mg/ml, Ethanol: insol, PBS (pH 7.2): insol. lambdamax: 220 nm. SMILES: CN(C1=CC=CC=C1)C([C@H](CC2=CC=CC=C2)NC(CC3=C(C)NC4=CC=CC=C34)=O)=O. InChi Code: InChI=1S/C27H27N3O2/c1-19-23(22-15-9-10-16-24(22)28-19)18-26(31)29-25(17-20-11-5-3-6-12-20)27(32)30(2)21-13-7-4-8-14-21/h3-16,25,28H,17-18H2,1-2H3,(H,29,31)/t25-/m0/s1. InChi Key: ACDFWSNAQWFRRF-VWLOTQADSA-N.