PF-06869206

PF-06869206 is an orally bioavailable inhibitor of sodium-phosphate cotransporter 2a (NaPi2a, IC50 = 380 nM). It is selective for NaPi2a over NaPi2b, NaPi2c, PiT-1, and PiT-2 (IC50s = >25 µM).Formal Name: 3-chloro-7-[(2S)-2-(hydroxymethyl)-4-morpholinyl]-2-methyl-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile. CAS Number: 2227425-05-8. Molecular Formula: C15H14ClF3N4O2. Formula Weight: 374.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/mL, DMSO: 1mg/mL, Ethanol: 10mg/mL, Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/mL. lambdamax: 209, 250, 282, 324 nm. SMILES: OC[C@H](C1)OCCN1C2=C3C(C(Cl)=C(C)N3)=NC(C(F)(F)F)=C2C#N. InChi Code: InChI=1S/C15H14ClF3N4O2/c1-7-10(16)11-12(21-7)13(23-2-3-25-8(5-23)6-24)9(4-20)14(22-11)15(17,18)19/h8,21,24H,2-3,5-6H2,1H3/t8-/m0/s1. InChi Key: ATFQBBCQZKVZJN-QMMMGPOBSA-N.