PF-06465469
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PF-06465469 is a covalent inhibitor of IL-2-inducible T cell kinase (Itk, IC50 = 2 nM). It also... more
Product information "PF-06465469"
PF-06465469 is a covalent inhibitor of IL-2-inducible T cell kinase (Itk, IC50 = 2 nM). It also inhibits Bruton's tyrosine kinase (BTK, IC50 = 2 nM). PF-06465469 inhibits Itk phosphorylation of phospholipase Cgamma (PLCgamma) induced by an anti-CD3 antibody in Jurkat cells (IC50 = 57 nM). It induces apoptosis in Jurkat cells, MOLT-4 and CCRF CEM T cell lymphoblasts, and Karpas-299 large cell lymphoma cells when used at a concentration of 16 µM. PF-06465469 (2 µM) inhibits chemotaxis induced by chemokine (C-X-C motif) ligand 12 (CXCL12) in Jurkat cells. SMILES NC1=C(C(C2=CC=CC(C(NC3=CC(C)=C(C(C)C)C=C3)=O)=C2)=NN4[C@@]5([H])CN(C(C=C)=O)CCC5)C4=NC=N1 InChi Code InChI=1S/C30H33N7O2/c1-5-25(38)36-13-7-10-23(16-36)37-29-26(28(31)32-17-33-29)27(35-37)20-8-6-9-21(15-20)30(39)34-22-11-12-24(18(2)3)19(4)14-22/h5-6,8-9,11-12,14-15,17-18,23H,1,7,10,13,16H2,2-4H3,(H,34,39)(H2,31,32,33)/t23-/m1/s1 InChi Key CGJVMKJGKFEHTL-HSZRJFAPSA-N
| Keywords: | 3-[4-amino-1-[(3R)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-N-[3-methyl-4-(1-methylethyl) phenyl]-benzamide |
| Supplier: | Cayman Chemical |
| Supplier-Nr: | 31118 |
Properties
| Application: | Itk covalent inhibitor |
| MW: | 523.63 D |
| Formula: | C30H33N7O2 |
| Purity: | >95% |
| Format: | Solid |
Database Information
| CAS : | 1407966-77-1| Matching products |
| KEGG ID : | K07363 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | -20°C (International: -20°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H315, H319, H335 |
| P Phrases: | P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362+364, P403+233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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