PF-06446846 hydrochloride

Item number	Size	Delivery time	Price
TGM-T16491-1mg	1 mg	7 - 10 business days*	49.00€
TGM-T16491-5mg	5 mg	7 - 10 business days*	115.00€
TGM-T16491-10mg	10 mg	7 - 10 business days*	196.00€
TGM-T16491-25mg	25 mg	7 - 10 business days*	468.00€
TGM-T16491-50mg	50 mg	7 - 10 business days*	705.00€
TGM-T16491-100mg	100 mg	7 - 10 business days*	1,032.00€

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Description: PF-06446846 hydrochloride, an orally active and highly selective inhibitor, targets... more

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Product information "PF-06446846 hydrochloride"

Description: PF-06446846 hydrochloride, an orally active and highly selective inhibitor, targets Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) translation by inducing ribosomal stalling at approximately codon 34, effectively suppressing PCSK9 expression. Target: Others. Smiles: Cl.Clc1cccnc1N([C@@H]1CCCNC1)C(=O)c1ccc(cc1)-n1nnc2cccnc12. References: Lintner NG, et al. Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain. PLoS Biol. 2017 Mar 21,15(3):e2001882.