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Item number: Cay20914-10

PF-06446846 is an inhibitor of proprotein convertase subtilisin kexin type 9 (PCSK9) translation. It inhibits translation of mRNA encoding PCSK9 by isolated human ribosomes when used at a concentration of 100 µM. PF-06446846 also inhibits PCSK9 secretion by Huh7 cells (IC50 = 0. µM). In vivo, PF-06446846 (50 mg/kg)...

Keywords:	N-(3-chloro-2-pyridinyl)-N-(3R)-3-piperidinyl-4-(3H-1,2,3-triazolo[4,5-b]pyridin-3-yl)-benzamide, hydrochloride
Application:	PCSK9 translation inhibitor
CAS	1632250-50-0
MW:	433.9 D

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PF-06446846 hydrochloride

Item number: TGM-T16491-10mg

Description: PF-06446846 hydrochloride, an orally active and highly selective inhibitor, targets Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) translation by inducing ribosomal stalling at approximately codon 34, effectively suppressing PCSK9 expression. Target: Others. Smiles:...

CAS	1632250-50-0

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