PF-06409577
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: PF-06409577 is an effective, orally active, and specific allosteric activator of... more
Product information "PF-06409577"
Description: PF-06409577 is an effective, orally active, and specific allosteric activator of AMPK (EC50: 7 nM, for alpha1beta1gamma1). Target: AMPK. Smiles: OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(cc1)C1(O)CCC1. References: Cameron K O, Kung D W, Kalgutkar A S, et al. Discovery and preClinicalal characterization of 6-chloro-5-[4-(1-hydroxycyclobutyl) phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577), a direct activator of adenosine monophosphate-activated protein kinase (AMPK), for the potential treatment of diabetic nephropathy[J]. Journal of medicinal chemistry, 2016, 59(17): 8068-8081.
| Keywords: | PF 06409577 |
| Supplier: | TargetMol |
| Supplier-Nr: | T4427 |
Properties
| Application: | AMPK heterotrimer activator |
| MW: | 341.79 D |
| Formula: | C19H16ClNO3 |
Database Information
| CAS : | 1467057-23-3| Matching products |
| KEGG ID : | K07199 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H315, H319, H335 |
| P Phrases: | P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362+364, P403+233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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