Perindoprilat

Perindoprilat is an inhibitor of angiotensin-converting enzyme (ACE, IC50 = 1.05 nM) and an active metabolite of the ACE inhibitor prodrug perindopril (Cay-20796). It reduces expression of the mRNA encoding VEGF in KB oral squamous cell carcinoma cells when used at concentrations of 1 and 2 µM. Perindoprilat, in combination with bradykinin, induces endothelium-dependent relaxation in isolated dog basilar and coronary arteries with 30% maximum induction (IC30) values of 0.46 and 1.15 µM, respectively. In vivo, perindoprilat (20 µg/kg) reverses or prevents restricted oxygen-induced decreases in mean blood pressure, renal blood flow, and renal vascular resistance, as well as increases in the urine flow rate in an acute hypoxemia-induced rabbit model of renal hypoperfusion.Formal Name: (2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-carboxybutyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic acid. CAS Number: 95153-31-4. Synonyms: S-9780. Molecular Formula: C17H28N2O5. Formula Weight: 340.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: [H][C@]12[C@](N(C([C@H](C)N[C@@H](CCC)C(O)=O)=O)[C@H](C(O)=O)C2)([H])CCCC1. InChi Code: InChI=1S/C17H28N2O5/c1-3-6-12(16(21)22)18-10(2)15(20)19-13-8-5-4-7-11(13)9-14(19)17(23)24/h10-14,18H,3-9H2,1-2H3,(H,21,22)(H,23,24)/t10-,11-,12-,13-,14-/m0/s1. InChi Key: ODAIHABQVKJNIY-PEDHHIEDSA-N.