PD 153035 (hydrochloride)

Overactivity of the epidermal growth factor receptor-associated tyrosine kinase (EGFR) has been associated with cancer development and progression, including cell proliferation, apoptosis, angiogenesis, and metastatic spread. PD 153035 is a highly potent, reversible inhibitor of the EGFR (Ki = 5.2 pM, IC50 = 29 pM). It has been shown to rapidly suppress autophosphorylation of EGFR in fibroblasts and human epidermoid carcinoma cells, as well as to selectively block EGF-mediated cellular processes, including mitogenesis and early gene expression.Formal Name: N-(3-bromophenyl)-6,7-dimethoxy-4-quinazolinamine, monohydrochloride. CAS Number: 183322-45-4. Synonyms: AG-1517. Molecular Formula: C16H14BrN3O2 . HCl. Formula Weight: 396.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.16 mg/ml, DMSO: 0.25 mg/ml. lambdamax: 221, 255, 346 nm. SMILES: COC(C(OC)=C1)=CC2=C1N=CN=C2NC3=CC(Br)=CC=C3.Cl. InChi Code: InChI=1S/C16H14BrN3O2.ClH/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11,/h3-9H,1-2H3,(H,18,19,20),1H. InChi Key: ZJOKWAWPAPMNIM-UHFFFAOYSA-N.