Parbendazole

Parbendazole is an inhibitor of microtubule assembly (EC50 = 3 µM). It reduces viability of HeLa cells (EC50 = 0.53 µM) and induces genotoxic stress in a reporter assay using HEK293 cells. Parbendazole reduces, but does not eradicate, worm burden in goats with naturally acquired or experimental nematode infections when administered at a dose of 15 mg/kg. It is teratogenic to lamb embryos when administered to pregnant ewes at a dose of 60 mg/kg during the third week of pregnancy.Formal Name: N-(6-butyl-1H-benzimidazol-2-yl)-carbamic acid, methyl ester. CAS Number: 14255-87-9. Synonyms: PBZ, SKF 29044. Molecular Formula: C13H17N3O2. Formula Weight: 247.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: slightly soluble. lambdamax: 210, 246, 287, 293 nm. SMILES: O=C(NC1=NC2=CC(CCCC)=CC=C2N1)OC. InChi Code: InChI=1S/C13H17N3O2/c1-3-4-5-9-6-7-10-11(8-9)15-12(14-10)16-13(17)18-2/h6-8H,3-5H2,1-2H3,(H2,14,15,16,17). InChi Key: YRWLZFXJFBZBEY-UHFFFAOYSA-N.