Paraxanthine

Description: Paraxanthine (1,7-dimethylxanthine) is a metabolite of caffeine (sc-202514) which functions as an adenosine receptor ligand and a PARP-1 inhibitor in pulmonary epithelial cells. Studies suggest that Paraxanthine is structurally similar to caffeine and possibly mediates the physiological effects of caffeine. Also Paraxanthine acts as a competitive phosphodiesterase inhibitor, which increases intracellular cAMP, activates PKA, inhibits TNF-alpha and leukotriene synthesis. In addition, Paraxanthine acts as a Na+/K+ ATPase enzymatic effector. Target: Endogenous Metabolite. Smiles: Cn1cnc2[nH]c(=O)n(C)c(=O)c12. References: Jiang M , Kameda K , Han L K , et al. Isolation of lipolytic substances caffeine and 1,7-dimethylxanthine from the stem and rhizome of Sinomenium actum[J]. Planta Medica, 1998, 64(04):375-377.