P11

P11
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay17507-500 500 µg -

6 - 10 business days*

43.00€
Cay17507-1 1 mg -

6 - 10 business days*

77.00€
Cay17507-5 5 mg -

6 - 10 business days*

308.00€
Cay17507-10 10 mg -

6 - 10 business days*

530.00€
 
Lipoprotein-associated phospholipase A2, also known as platelet activating factor acetylhydrolase... more
Product information "P11"
Lipoprotein-associated phospholipase A2, also known as platelet activating factor acetylhydrolase (PAF-AH) or phospholipase A2 group 7, hydrolyzes glycerophospholipids to produce lyso-PAF/lyso-phosphatidylcholine and short and/or oxidized fatty acids, many of which have pro-inflammatory or pro-oxidative activities. PAF-AH1b2 and 1b3 form a complex with 1b1 to regulate brain development, spermatogenesis, and cancer pathogenesis. P11 is an inhibitor of PAF-AH1b2- and 1b3-mediated hydrolysis of PAF to lyso-PAF (IC50s = 37 and 880 nM, respectively) without significant effect on other brain serine hydrolases. At 10 µM, it has been shown to impair Neuro2a and PC3 tumor cell survival.Formal Name: (2R,6R)-rel-2-[4-(1,1-dimethylethyl)phenyl]-1,2,5,6-tetrahydro-6-(4-methylphenyl)-1-[(4-methylphenyl)sulfonyl]-3-pyridinecarboxylic acid. CAS Number: 942285-55-4. Molecular Formula: C30H33NO4S. Formula Weight: 503.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml. SMILES: OC(C1=CC[C@@H](C2=CC=C(C)C=C2)N(S(C3=CC=C(C)C=C3)(=O)=O)[C@H]1C4=CC=C(C(C)(C)C)C=C4)=O. InChi Code: InChI=1S/C30H33NO4S/c1-20-6-10-22(11-7-20)27-19-18-26(29(32)33)28(23-12-14-24(15-13-23)30(3,4)5)31(27)36(34,35)25-16-8-21(2)9-17-25/h6-18,27-28H,19H2,1-5H3,(H,32,33)/t27-,28-/m0/s1. InChi Key: KUBDPRSHRVANQQ-NSOVKSMOSA-N.
Keywords: (2R,6R)-rel-2-[4-(1,1-dimethylethyl)phenyl]-1,2,5,6-tetrahydro-6-(4-methylphenyl)-1-[(4-methylphenyl)sulfonyl]-3-pyridinecarboxylic acid
Supplier: Cayman Chemical
Supplier-Nr: 17507

Properties

Application: PAF-AH1b2/3 inhibitor
MW: 503.7 D
Formula: C30H33NO4S
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 942285-55-4| Matching products
KEGG ID : K01062 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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