p-chloro Phenylalanine

p-chloro Phenylalanine is an inhibitor of tryptophan hydroxylase (Ki = 300 µM). It acts as a competitive inhibitor in vitro and an irreversible inhibitor in vivo. It depletes serotonin to undetectable levels in rats after six days when administered at a dose of 300 mg/kg. p-chloro Phenylalanine has commonly been used to deplete brain serotonin levels in animal studies of the serotonergic system and its involvement in depressive-like behavior, reward learning, Parkinson's disease, and pain.Formal Name: 4-chloro-phenylalanine. CAS Number: 7424-00-2. Synonyms: 4-chloro Phenylalanine, CP 10188, Fenclonine, NSC 77370, para-chloro Phenylalanine, PCPA. Molecular Formula: C9H10ClNO2. Formula Weight: 199.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Ethanol: Slightly Soluble, Methanol: Slightly Soluble. lambdamax: 222, 260, 322 nm. SMILES: ClC1=CC=C(CC(N)C(O)=O)C=C1. InChi Code: InChI=1S/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13). InChi Key: NIGWMJHCCYYCSF-UHFFFAOYSA-N.