OSMI-1

OSMI-1 is a quinolinone-6-sulfonamide that inhibits O-GlcNAc transferase (OGT, IC50 = 2.7 µM) in vitro. It is cell permeable and inhibits global O-GlcNAcylation in a dose-dependent manner in CHO cells. OSMI-1 induces a mass shift of nucleoporin62 (Nup62) that corresponds to the loss of O-GlcNAc residues and decreases levels of cellular O-GlcNAcase (OGA). OSMI-1 (50 µM) also causes a 50% decrease in CHO cell viability after 24 hours.Formal Name: alphaR-[[(1,2-dihydro-2-oxo-6-quinolinyl)sulfonyl]amino]-N-(2-furanylmethyl)-2-methoxy-N-(2-thienylmethyl)-benzeneacetamide. CAS Number: 1681056-61-0. Molecular Formula: C28H25N3O6S2. Formula Weight: 563.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/mL, DMF:PBS (pH 7.2) (1:5): 0.16 mg/mL, DMSO: 20 mg/mL. lambdamax: 245, 327 nm. SMILES: O=C([C@@H](C1=CC=CC=C1OC)NS(C2=CC(C=CC(N3)=O)=C3C=C2)(=O)=O)N(CC4=CC=CO4)CC5=CC=CS5. InChi Code: InChI=1S/C28H25N3O6S2/c1-36-25-9-3-2-8-23(25)27(28(33)31(17-20-6-4-14-37-20)18-21-7-5-15-38-21)30-39(34,35)22-11-12-24-19(16-22)10-13-26(32)29-24/h2-16,27,30H,17-18H2,1H3,(H,29,32)/t27-/m1/s1. InChi Key: IYIGLWQQAMROOF-HHHXNRCGSA-N.