Osilodrostat

Osilodrostat is an inhibitor of aldosterone synthase (IC50 = 0.7 nM for the recombinant human enzyme). It is selective for human aldosterone synthase over rat aldosterone synthase (IC50 = 160 nM). Osilodrostat inhibits increases in plasma aldosterone levels induced by angiotensin II or adrenocorticotropic hormone (ACTH) in rats (ED50s = 0.6 and 1.1 mg/kg, respectively). It reduces mean arterial pressure and prolongs survival in rats expressing human renin and angiotensinogen, a double-transgenic model of angiotensin II-dependent hypertension, in a dose-dependent manner. Formulations containing osilodrostat have been used in the treatment of Cushing's syndrome.Formal Name: 4-[(5R)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl]-3-fluoro-benzonitrile. CAS Number: 928134-65-0. Synonyms: LCI699. Molecular Formula: C13H10FN3. Formula Weight: 227.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml. lambdamax: 227 nm. SMILES: FC1=C(C=CC(C#N)=C1)[C@]2([H])N3C(CC2)=CN=C3. InChi Code: InChI=1S/C13H10FN3/c14-12-5-9(6-15)1-3-11(12)13-4-2-10-7-16-8-17(10)13/h1,3,5,7-8,13H,2,4H2/t13-/m1/s1. InChi Key: USUZGMWDZDXMDG-CYBMUJFWSA-N.