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Item number: TGM-T4277-10mg

Description: Osilodrostat (LCI699) (LCI699) is an effective inhibitor of human 11beta-hydroxylase (IC50: 2.5 nM) and aldosterone synthase (IC50: 0.7 nM). Target: Others, Hydroxylase, Glucocorticoid Receptor. Smiles: Fc1cc(ccc1[C@H]1CCc2cncn12)C#N. References: Li L, et al. Osilodrostat (LCI699), a potent...

Keywords:	LCI699
Application:	Targets steroid 11beta-monooxygenase / corticosterone 18-monooxygenase (CYP11B2)
CAS	928134-65-0
MW:	227.24 D

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Osilodrostat

Item number: Cay33928-10

Osilodrostat is an inhibitor of aldosterone synthase (IC50 = 0.7 nM for the recombinant human enzyme). It is selective for human aldosterone synthase over rat aldosterone synthase (IC50 = 160 nM). Osilodrostat inhibits increases in plasma aldosterone levels induced by angiotensin II or adrenocorticotropic hormone...

Keywords:	LCI699, 4-[(5R)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl]-3-fluoro-benzonitrile
Application:	Aldosterone synthase inhibitor
CAS	928134-65-0
MW:	227.2 D

From 119.00€ *

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