Orexin 2 Receptor Agonist

Orexin 2 receptor agonist is an agonist of the orexin 2 receptor (OX2R) with an EC50 value of 23 nM in a calcium influx assay. It is 70-fold selective for OX2R over OX1R (EC50 = 1,616 nM).Formal Name: 4'-methoxy-N,N-dimethyl-3'-[[[3-[[2-[(3-methylbenzoyl)amino]ethyl]amino]phenyl]amino]sulfonyl]-[1,1'-biphenyl]-3-carboxamide. CAS Number: 1796565-52-0. Synonyms: OX2R. Molecular Formula: C32H34N4O5S. Formula Weight: 586.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml, DMSO: 20 mg/ml. lambdamax: 210, 252 nm. SMILES: O=S(NC1=CC(NCCNC(C2=CC=CC(C)=C2)=O)=CC=C1)(C3=C(OC)C=CC(C4=CC(C(N(C)C)=O)=CC=C4)=C3)=O. InChi Code: InChI=1S/C32H34N4O5S/c1-22-8-5-10-25(18-22)31(37)34-17-16-33-27-12-7-13-28(21-27)35-42(39,40)30-20-24(14-15-29(30)41-4)23-9-6-11-26(19-23)32(38)36(2)3/h5-15,18-21,33,35H,16-17H2,1-4H3,(H,34,37). InChi Key: RHLMXWCISNJNDH-UHFFFAOYSA-N.