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| Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
|---|---|---|---|---|---|---|---|
| Cay45601-5 | 5 mg | - |
6 - 10 business days* |
264.00€
|
|||
| Cay45601-10 | 10 mg | - |
6 - 10 business days* |
395.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
OPB-171775 is a molecular glue. It induces the formation of a complex between phosphodiesterase... more
Product information "OPB-171775"
OPB-171775 is a molecular glue. It induces the formation of a complex between phosphodiesterase 3A (PDE3A) and ribonuclease SLFN12. OBI-171775 (10 nM) induces G0/G1 phase cell cycle arrest, apoptosis, and necrosis in PFSK-1 primitive neuroectodermal tumor cells, with cell cycle arrest partially blocked by the general control nonderepressible 2 kinase (GCN2) inhibitor GCN2iB (Cay35897). It reduces tumor volume and induces tumor regression in patient-derived xenograft (PDX) mouse models of a variety of cancer types, including gastrointestinal stromal tumor (GIST), ovarian, and lung cancers. OPB-171775 (0.03 mg/kg) reduces tumor growth in a GS11353 PDX mouse model of GIST, with tumor eradication when administered in combination with imatinib (Cay13139).. SMILES: FC1=C(C2=NNC(C[C@H]2C)=O)C=CC(OCC(C)(O)C)=C1F. InChi Code: InChI=1S/C15H18F2N2O3/c1-8-6-11(20)18-19-14(8)9-4-5-10(13(17)12(9)16)22-7-15(2,3)21/h4-5,8,21H,6-7H2,1-3H3,(H,18,20)/t8-/m1/s1. InChi Key: GGUTYKLJESECBW-MRVPVSSYSA-N
| Keywords: | 6-[2,3-difluoro-4-(2-hydroxy-2-methylpropoxy)phenyl]-4,5-dihydro-5-methyl-3(2H)-pyridazinone |
| Supplier: | Cayman Chemical |
| Supplier-Nr: | 45601 |
Properties
| Application: | Molecular glue |
| MW: | 312.32 D |
| Formula: | C15H18F2N2O3 |
| Purity: | >98% |
| Format: | Solid |
Database Information
| CAS : | 2131210-15-4| Matching products |
| KEGG ID : | K24457 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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