Oleandrin

Description: 1. Oleandrin (Folinerin), the principal cardiac glycoside component of PBI-524, can quantitatively account for regulation of BDNF at both the protein and transcriptional levels. 2. Oleandrin are known to inhibit the Na, K-ATPase pump, resulting in a consequent increase in calcium influx in heart muscle. 3. Oleandrin has stronger anti-proliferative activity in undifferentiated CaCO-2 cells (IC50, 8.25 nM) , causes an autophagic cell death and altered ERK phosphorylation in undifferentiated. Target: Apoptosis, Potassium Channel, ATPase, Sodium Channel. Smiles: [H][C@]12CC[C@]3([H])[C@]([H])(CC[C@]4(C)[C@H]([C@H](C[C@]34O)OC(C)=O)C3=CC(=O)OC3)[C@@]1(C)CC[C@@H](C2)O[C@H]1C[C@H](OC)[C@@H](O)[C@H](C)O1. References: Pan L, Zhang Y, Zhao W, et al. The cardiac glycoside oleandrin induces apoptosis in human colon cancer cells via the mitochondrial pathway[J]. Cancer Chemotherapy and Pharmacology. 2017 Jul,80(1):91-100.